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Isordil is indicated for the prevention of angina pectoris due to coronary artery disease.


Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

You should take this medicine first thing in the morning and follow the same schedule each day. Do not chew, crush, or swallow sublingual tablets. Do not eat, drink, smoke, or use chewing tobacco while a tablet is dissolving.


  • For angina prevention:
  • For oral dosage form (extended-release tablets, sustained-release capsules):
    Adults—At first, 40 milligrams (mg) two times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 160 mg per day.
    Children—Use and dose must be determined by your doctor.
  • For oral dosage form (tablets):
    Adults—At first, 5 to 20 milligrams (mg) two or three times a day. Your doctor may increase your dose as needed.
    Children—Use and dose must be determined by your doctor.
  • For sublingual dosage form (tablets):
    Adults—2.5 to 5 milligrams (mg) about 15 minutes before expected physical or emotional stress.
    Children—Use and dose must be determined by your doctor.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines.

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Congestive heart failure or
Heart attack, recent or
Hypertrophic cardiomyopathy (a heart disease) or
Hypotension (low blood pressure) or
Hypovolemia (low amount of blood)—Use with caution. May make these conditions worse.

Do not take sildenafil (Viagra®), tadalafil (Cialis®), or vardenafil (Levitra®) while you are using this medicine. Using these medicines together may cause blurred vision, dizziness, lightheadedness, or fainting.

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Check with your doctor immediately if any of the following side effects occur:
Bluish-colored lips, fingernails, or palms
dark urine
difficulty with breathing
dizziness or lightheadedness
pale skin
rapid heart rate
shortness of breath
sore throat
unusual bleeding or bruising
unusual tiredness or weakness
Incidence not known
Arm, back, or jaw pain
blurred vision
chest pain or discomfort
chest tightness or heaviness
dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
fast or irregular heartbeat

Get emergency help immediately if any of the following symptoms of overdose occur:
Symptoms of overdose
Blurred or loss of vision
bulging soft spot on the head of an infant
change in consciousness
change in the ability to see colors, especially blue or yellow
cold, clammy skin
disturbed color perception
double vision
fast, irregular, pounding, or racing heartbeat or pulse
feeling of constant movement of self or surroundings
halos around lights
headache, severe and throbbing
increased sweating
loss of appetite
loss of consciousness
night blindness
overbright appearance of lights
sensation of spinning
slow heartbeat
tunnel vision

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